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—Doctor, ____________should I take this medicine?
—Twice a day.
A. what time         B. how much        C. how often
C

试题分析:句意为:---医生,我应该多久服一次这个药?---每天两次。what time :提问时间,什么时候; how much:提问数量、价格多少, how often:提问动作发生的频率,多久一次。根据语境可知应选C。
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