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In those days ,books could only be produced one at a time _____________.

A.in hand B.with hand 
C.by hand D.by hands

C

解析试题分析:in hand  在手头,在控制中;with hand用手;by hand   用手,手工的;by hands无此说法。句意:在哪个时代,书籍只能手工一本一本地写。With一般表示用某种工具,by表示用某种方式,结合语境可知本句中强调书籍的生产方式,故选C。
考点:考查介词短语。

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