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_____the beginning of the 19th century did scientists know that all matter is made up of atoms.
A,At     B,By     C,Up to     D,Not until
D

试题分析:句子用了部分倒装,所以前面用Not until
点评:句首状语为否定词或半否定词的句子。这类词或短语主要有never, neither, nor, little, seldom(很少,不常), rarely(很少,罕有), hardly, scarcely(几乎不,简直没有), no sooner(立即), not only, in no way(决不), at no time, few, not, no等, 用部分倒装。部分倒装是把be动词、情态动词、助动词放到主语之前。如果句子中没有这些词,要在主语之前加助动词do / does / did等,而把原来的谓语动词变成原形放在主语之后。
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