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---She has tried many kinds of medicine.

---But ______ has any effect on her disease.


  1. A.
    nothing
  2. B.
    none
  3. C.
    little
  4. D.
    no one
B
句意:--她已试了许多种药。--但没有一种药对她的病有效。四个选项中可以首先排除C、D两项;nothing 往往与something, anything一起连用,而本句中前面是一名词medicine,故被排除。只有B项none可以代替前面的名词。
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