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By the time he realizes he _____ a mistake, it’ll be too late for him to change his mind.    
A.makesB.madeC.has madeD.had made
C
考察时态。By与完成时连用,且by the time引导是时间状语从句,,使用一般现在时表示将来时,主句使用将来时。根据句意可知是他认识到自己已经犯了错误。
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