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—How amazing it is that astronauts are exploring outer space!

—It's a challenge, I guess, ______ man against nature.

A. of B. for

C. by D. about

 

A

【解析】A 考察介词。应答句中的I guess是插入语,因此所填介词与challenge连用,表所属,使用of。选A。句义:我猜想它是人对自然的挑战。

 

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