17.Scientists have overcome a major difficulty for humans to receive life-saving organ transplants from pigs,thanks to a powerful new gene-editing technique.
In a paper in the US journal Science,the researchers described using gene-editing method to remove potentially harmful DNA sequences at 62locations,which are the remnants(留存之处) of a virus called PERV,from the pig genome.
Globally human organs for transplant being short in supply,researchers and doctors have long hoped that the problem could be solved through the availability of suitable animal organs for transplant,a concept known as xenotransplantation.
Pigs have been especially promising candidates due to their similar size and biological structure to humans.
But one of the largest safety concerns has been the fact that pigs,similar to most mammals,contain PERVs in all their living cells-that are harmless to their native hosts but can cause disease in other species.
"PERVs and the lack of ability to remove them from pig DNA was a real barrier on the promising stage set for xenotransplantation."
In the new study,scientists made 62genetic edits to inactivate viruses in pig cells,which they called"an explosive leap forward".
When these cells were then introduced to human cells in the lab,PERV infectivity was reduced by up to one thousand fold,they said.
"Our work got away the shadow PERVs put above the field more than a decade ago when the virus was discovered,while renewing our faith in xenotransplantation,"lead author Luhan Yang,a post-doctoral fellow at the Harvard University,said.
The team hopes eventually they can completely root out the risk that PERVs could cause disease in xenotransplantation by using modified pig cells to clone a line of pigs that would have their PERV genes inactivated."We still have a long way to go,though."Luhan added.
33.From the passage,we may know thatD.
A.PERV is found during Luhan Yang's experiments
B.PERV infecting rate has been reduced to 1‰now
C.the breakthrough is the result of a decade-long project
D.PERV is not a threat to same species in organ transplantation
34.Which of the following is TRUE?C
A.Explosive materials are used in experiments.
B.Experiments are carried out in 62locations in US.
C.Further research is still needed in Xenotransplantation.
D.Gene-editing method is used to remove harmful pig organs.
35.Which would be the best title for the passage?D
A.A big breakthrough in scientific field.
B.Viruses in pig cells are inactivated.
C.Viruses are defeated by scientists.
D.New hope in xenotransplantation.
分析 本文主要讲述了在器官移植方面需要克服的一个病毒问题,但是随着科学研究的进展,异种移植是有可能成为现实的.
解答 33.D 细节题.根据文章内容,the researchers described using gene-editing method to remove potentially harmful DNA sequences at 62locations,which are the remnants(留存之处) of a virus called PERV,from the pig genome…Pigs have been especially promising candidates due to their similar size and biological structure to humans由此可知,科学家已经使用了一种新的基因剪辑方式来移除病毒PERV,它对于同种类型的器官移植已不在是威胁,结合选项,故选D
34.C 推理题.根据文章内容,The team hopes eventually they can completely root out the risk that PERVs could cause disease in xenotransplantation by using modified pig cells to clone a line of pigs that would have their PERV inactivated."We still have a long way to go,though."Luhan added.研究团队希望以后能够用现代的猪身上的细胞来克隆出相应的使用在异种移植上.在这条路上,需要走的路还长,还有许多的工作需要做,结合选项,故选C
35.D 主旨题.根据文章内容,主要讲述了在器官移植方面需要克服的一个病毒问题,但是随着科学研究的进展,异种移植是有可能成为现实的.结合选项,故选D
点评 本文是一个科教类阅读理解,题目涉及多道细节理解题,做题时结合原文和题目有针对性的找出相关语句进行仔细分析,结合选项选出正确答案.推理判断题也是要在抓住关键句子的基础上合理的分析才能得出正确答案,切忌胡乱猜测,一定要做到有理有据.