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It was along the Mississippi River _________ Mark Twain spent much of his childhood.
A.howB.whichC.thatD.where
C
考察连词。根据句子结构可知,该句为强调句,强调句的特点是去掉it was  that 以后句子结构完整,即Mark Twain spent much of his childhood along the Missippi River.
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