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    She looks sad. Could you please tell me ____ that prevents her from being as happy as before?
    A．what it isB．it is whatC．how it isD．it is how
    A
    本题含有强调句型，若把It is···that去掉，则很容易地看出what引导的宾语从句，what在从句中充当主语。故选A。
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