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He tried his best to solve the problem,     difficult it was.  
A.no matter whatB.whateverC.howeverD.how
C               
             
试题分析:考查状语从句。句意:他努力去解决这个问题,无论它有多么的困难。后半句是让步状语从句,however相当于no matter how 后面跟形容词或副词,而whatever 等于no matter what后面跟名词,故选C项。          
考点 : 考查状语从句
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