Modern science has given clear evidence ________ smoking can lead to many diseases．

A．what

B．which

C．that

D．where

The notice came around two in the afternoon ________ the meeting would be postponed．

A．when

B．that

C．whether

D．how

There is little doubt in your mind that he is innocent, ________?

A．is there

B．isn't there

C．is he

D．isn't he

Sophia waited for a reply, but ________ came．

A．either

B．another

C．neither

D．none

After the flooding, people were suffering in that area, ________ urgently needed clean water, medicine and shelter to survive．

A．which

B．who

C．where

D．what

It is generally considered unwise to give a child ________ he or she wants．

A．however

B．whatever

C．whichever

D．whenever

The officer insisted that Michael did not follow the correct ________ in applying for a visa．

A．pattern

B．procedure

C．program

D．perspective

It is important to have your eyes examined regularly to check for any sign of eye disease that may not have any ________．

A．symptom

B．similarity

C．sample

D．shadow

Whether the buildings in this area should be pulled down has remained ________; people are still looking for other possible solutions．

A．unchallenged

B．relevant

C．controversial

D．contradictory

Can you tell the ________ difference between the words “require” and “request”? I sometimes get puzzled by their meanings．

A．dramatic

B．regional

C．apparent

D．subtle