Have you noticed the problem ___ he is now in low spirit ? ____ come?

            A. where, What         B. that, How    C. in which, For         D. what, As

Have you noticed the problem ___ he is now in low spirit ? 

____ come?

1. A.
   where, What
2. B.
   that, How
3. C.
   in which, For
4. D.
   what, As