解:(1)2.5×8×0.4×0.125,
=(2.5×0.4)×(8×0.125),
=1×1,
=1;
(2)0.65×201,
=0.65×200+0.65×1,
=130+0.65,
=130.65;
(3)6.81+6.81×99,
=6.81×(1+99),
=6.81×100,
=681;
(4)(1×2×3…10×11)÷(27×25×24×22),
=(1×2×3…10×11)÷(11×2×6×4×5×5×3×9),
=
,
=7×8×2,
=112;
分析:(1)2.5×8×0.4×0.125,运用乘法的交换律和结合律进行简算;
(2)0.65×201,运用乘法分配律进行简算;
(3)6.81+6.81×99,运用乘法分配律进行简算;
(4)(1×2×3…10×11)÷(27×25×24×22),将除数转化为:(11×2×6×4×5×5×3×9),再根据除法与分数的联系写成分数的形式,然后进行约分即可;
点评:解决简算的题目,一定要仔细审题,运用运算技巧或运算定律,灵活简算.